Commentary: For whom the bells knell

For whom the bells toll: Networked circadian clocks

Circadian cycles are robust and precise biological rhythms common in unicellular and multicellular organisms. Single cells have been shown to sustain autonomous near 24-h rhythms, however, many cells and tissues appear to require cell–cell interactions to maintain periodicity. This review highlights the mechanisms and benefits of coupling circadian oscillators. We focus on how populations of ci...

For whom the desert bell tolls: heat stroke or stroke

       Heat stroke is the most complicated and dangerous amongst heat injuries that can lead to irreversible injury and even death with itself or with creating predisposibility to different diseases. The following case report depicts a patient who presented primarily with impairment of consciousness after walking 45 km in the summer heat to cross the Syria-Turkey border and la...

NSA’s MORECOWBELL: Knell for DNS

On the net, close to everything starts with a request to the Domain Name System (DNS), a core Internet protocol to allow users to access Internet services by names, such as www.example.com, instead of using numeric IP addresses, like 2001:DB8:4145::4242. Developed in the “Internet good old times” the contemporary DNS is like a large network activity chart for the visually impaired. Consequently...

Sounding the Death Knell for In Loco Parentis

A death knell for relapsed leukemia?

Phagocytes patrol intestinal fungi Maintaining a healthy balance of gut bacteria can promote good health. Leonardi et al. show that fungi can also interact with gut immune cells to maintain intestinal wellbeing. CX3CR1 mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms ...